Agrimony Citations

Bibliography for the genus Agrimonia

• Ellingwood: pg. 429
• King's American Dispensatory: pg. 129
• British Herbal Pharmacopoeia,: pg.
• Handbook of Medicinal Herbs: pg.
• Herbal Medicine: pg. 92
• Potter's: pg. 5

Citations from the Medline database

AMERICAN JOURNAL OF CHINESE MEDICINE
Wang JP Hsu MF Teng CM
Antihemostatic effect of Hsien-Ho-T'sao (Agrimonia pilosa).
Am J Chin Med 1984 Summer;12(1-4):116-23
Bleeding time in rats was markedly prolonged after the administration of the water extract of Hsien-Ho-T'sao. This antihemostatic effect was more marked in the group of i.p. injection of the drug than in the group of p.o. administration for 2 or 7 consecutive days. Blood coagulation studies showed that plasma prothrombin time, activated partial thromboplastin time and stypven time were prolonged, while thrombin time and fibrinogen level were not changed. The thromboelastographic recording showed that reaction time was prolonged and maximal elasticity of clot was decreased. In addition, ADP- and collagen- induced aggregations of platelet-rich plasma were suppressed. In conclusion, the prolongation of the bleeding time might be due to both anticoagulant and antiplatelet action of the drug.

Hsu MF Young JH Wang JP Teng CM
Effect of hsien-ho-t'sao (Agrimonia pilosa) on experimental thrombosis in mice.
Am J Chin Med 1987;15(1-2):43-51
The water extract of Hsien-Ho-T'sao (HHT) prolonged the tail bleeding time in conscious mice. This antihemostatic effect was dose-dependent and exhibited a biphasic pattern; i.e. its activity declined at doses higher than 0.5 mg/kg. the prolonged bleeding time persisted for at least 12 hr and maximal effect was observed at 3 hr after the oral administration of HHT 500 mg/kg. HHT was effective in preventing ADP- induced acute pulmonary thromboembolic death in mice, while aspirin and indomethacin had no effect on this model. HHT, like aspirin and indomethacin, also reduced the mortality in collagen- and sodium arachidonate-induced thromboembolic death. All three drugs caused no significant protection in endotoxin shock. HHT was found to suppress platelet aggregation markedly, but little effect on blood coagulation. In conclusion, HHT was proved to be effective in the treatment of acute pulmonary thromboembolism, and this effect was mainly due to its antiplatelet action.

Wang JP Hsu MF Teng CM
Antiplatelet effect of hsien-ho-t'sao (Agrimonia pilosa).
Am J Chin Med 1985;13(1-4):109-18
The water extract of Hsien-Ho-T'sao (HHT) produced a dose-dependent inhibition on collagen-induced aggregation of platelet-rich plasma (PRP). The IC50 was about 3.5 mg/ml. In addition, HHT inhibited also the aggregation induced by ADP, A23187 or arachidonate in PRP. Greater inhibition was observed in the preparation of washed platelets. Increase of the calcium concentration in medium could not overcome the inhibitory effect of HHT. ATP release from platelets induced by collagen or A23187 was inhibited by HHT. In the presence of EDTA, ATP release caused by thrombin or A23187 was also inhibited by HHT. Malondialdehyde and thromboxane B2 formation was greatly inhibited by HHT in platelets challenged by collagen and thrombin. In arachidonate-stimulated platelets, thromboxane B2, but not malondialdehyde formation was inhibited. HHT showed more marked inhibition on aggregation in the presence of indomethacin, creatine phosphate/creatine phosphokinase or a combination of both. Hydrogen peroxide-induced hemolysis was marked reduced by HHT. It was concluded that HHT might have some membrane-active properties which interfered with the activation of phospholipase A2.

BOLLETTINO - SOCIETA ITALIANA BIOLOGIA SPERIMENTALE
Giachetti D Taddei E Taddei I
[Diuretic and uricosuric activity of Agrimonia eupatoria L.]
Ricerche sull'attivita diuretica ed uricosurica di Agrimonia eupatoria L.
Boll Soc Ital Biol Sper 1986 Jun 30;62(6):705-11 (Published in Italian)

CANCER IMMUNOLOGY, IMMUNOTHERAPY
Miyamoto K Kishi N Murayama T Furukawa T Koshiura R
Induction of cytotoxicity of peritoneal exudate cells by agrimoniin, a novel immunomodulatory tannin of Agrimonia pilosa Ledeb.
Cancer Immunol Immunother 1988;27(1):59-62
The cytotoxic activities of the PEC after an i.p. injection of agrimoniin, a tannin contained in Agrimonia pilosa Ledeb. were studied. The plastic nonadherent PEC had significantly higher NK cell activity than the untreated control, and the adherent PEC were cytostatic toward MM2 and MH134 cells. The adherent PEC did not cause tumor cell lysis by themselves, but were cytolytic against MM2 cells in the presence of anti-MM2 sera. In the course of these effects of PEC after the i.p. injection of agrimoniin, the augmentation of NK cell activity was the earliest reaction, reaching a peak at 2 days after the injection; then, cytostatic activity increased. The induction of antibody-dependent cell lytic activity was a later reaction, which reached a peak at 6 days after the injection.

CESKOSLOVENSKA FARMACIE
Buckova A Eisenreichova E Leifertova I Licha K
[Pharmacobotanical study of the genus Agrimonia. 3. Phenolic substances and saccharides in Agrimonia eupatoria L. ssp. eupatoria and Agrimonia procera Wallr]
Farmakobotanicke studium rodu Agrimonia. 3. Hodnotenie fenolickych latok a sacharidov vo vnati Agrimonia eupatoria L. ssp. eupatoria a Agrimonia procera Wallr.
Cesk Farm 1972 Jul;21(6):244-8 (Published in Slovak)

Buckova A Leifertova I Natherova L Skalicky V
[Pharmacobotanical study of the genus Agrimonia. II. Evaluation of tannin in European Agrimonias]
Farmakobotanicke studium rodu Agrimonia. II. Hodnoceni trislovin evropskych repik~u.
Cesk Farm 1971;20(4):136-40 (Published in Czech)

Skalicky V Leifertova I
[Pharmacobotanical study of family Agrimonia. I. Evaluation of Agrimonia eupatoria L. subsp. eupatoria and Agrimonia procera Wallr]
Farmakobotanicke studium rodu Agrimonia. I. Zhodnoceni Agrimonia eupatoria L. subsp. eupatoria a Agrimonia procera Wallr.
Cesk Farm 1969;18(7):329-36 (Published in Czech)

CHUNG-HUA I HSUEH TSA CHIH [CHINESE MEDICAL JOURNAL]
[Agrimophol structure--the taenifugal constituent from root-sprout of Agrimonia pilosa ledeb]
Chung Hua I Hsueh Tsa Chih 1974;6:346-7 (Published in Chinese)

FARMATSIIA
Gorodnianskaia LM Liapunova PN Balanda PP
[Diagnostic traits of common agrimony (Agrimonia eupatoria L.), a herbal raw material]
Diagnosticheskie priznaki syr'ia travy repeinichka aptechnogo (Agrimonia eupatoria L.).
Farmatsiia 1978 Jan-Feb;27(1):34-8 (Published in Russian)

JAPANESE JOURNAL OF PHARMACOLOGY
Miyamoto K Kishi N Koshiura R
Antitumor effect of agrimoniin, a tannin of Agrimonia pilosa Ledeb., on transplantable rodent tumors.
Jpn J Pharmacol 1987 Feb;43(2):187-95
The effect of agrimoniin, a tannin contained in Agrimonia pilosa LEDEB., on ascites type and solid type rodent tumors was investigated. When agrimoniin was intraperitoneally (i.p.) administered at dosages over 10 mg/kg before or after the MM2 cell i.p. inoculation, this tannin almost completely rejected the tumor growth in the mice. This tannin prolonged the life span of mice bearing MM2 or cured by the intravenous or per oral pre- or postmedication. Agrimoniin also inhibited the growth of MH134 and Meth-A solid type tumors. Agrimoniin showed strong cytotoxicity on MM2 cells in vitro, but the activity was diminished to about 4% of the initial activity by the addition of fetal calf serum to the culture. On the other hand, i.p. injection of agrimoniin increased the number of peripheral white blood cells and the ratio of monocytes. On the 4th day after the i.p. injection of the tannin, cytotoxic adherent peritoneal exudate cells were also increased. The spleen of the mice was enlarged, and the spleen cells possessed the capacity to take up 3H-thymidine. Agrimoniin showed weak direct migration activity against spleen cells from non-treated mice. These results indicate that agrimoniin is a potent antitumor tannin and suggest that the antitumor effect may be due to this tannin enhancing the immune response of the host animals through the actions on tumor cells and some immunocytes.

Koshiura R Miyamoto K Ikeya Y Taguchi H
Antitumor activity of methanol extract from roots of Agrimonia pilosa Ledeb.
Jpn J Pharmacol 1985 May;38(1):9-16
To evaluate the antitumor activity of Agrimonia pilosa LEDEB., the effects of the methanol extract from roots of the plant (AP-M) on several transplantable rodent tumors were investigated. AP-M significantly prolonged the life span of S180-, Meth-A fibrosarcoma- and MM-2 mammary carcinoma-bearing mice by intraperitoneal (i.p.) pre- or postmedication. AP-M also inhibited the growth of S-180 solid type tumor. On the other hand, the prolongation of life span induced by AP-M on S-180 ascites type tumor-bearing mice was markedly minimized or abolished by the pretreatment of cyclophosphamide. AP-M showed considerably strong cytotoxicity on MM-2 cells in vitro, but the effect was diminished to one-tenth by the addition of serum to the culture. Against the host animals, the peripheral white blood cells in mice were significantly increased from 2 to 5 days after the i.p. injection of AP-M. On 4th day after the injection of AP-M, the peritoneal exudate cells which possessed the cytotoxic activity on MM- 2 cells in vitro were also increased to about 5-fold those in the non- treated control. The spleen of the mice was enlarged, and the spleen cells possessed the capacity to uptake 3H-thymidine. However, AP-M did not show direct migration activity like other mitogens against spleen cells from non-treated mice. These results indicate that the roots of Agrimonia pilosa contain some antitumor constituents, and possible mechanisms of the antitumor activity may be some host- mediated actions and direct cytotoxicity.

PHARMAZIE
Peter MH Racz G
[The tannin content of various Agrimonia species]
Der Gerbstoffgehalt verschiedener Agrimoniaarten. Pharmazie 1973 Aug;28(8):539-41 (Published in German)

Peter HM
[Antibiotic effect of extracts from Agrimonia-variety]
Die antibiotische Wirkung von Auszugen aus Agrimonia-Arten. Pharmazie 1969 Oct;24(10):632-5 (Published in German)

YAKUGAKU ZASSHI. JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
Koshiura R Miyamoto K Takada Y Kiriyama N
[Studies on the constituents of Agrimonia pilosa Ledeb. I. Biological activities of the acidic fraction soluble in n-hexane of the roots (author's transl)]
Yakugaku Zasshi 1980 Nov;100(11):1167-70 (Published in Japanese)

Kimura Y Takido M Yamanouchi S
[Studies on the standardization of crude drugs. XI. Constituents of Agrimonia pilosa var. japonica]
Yakugaku Zasshi 1968 Oct;88(10):1355-7 (Published in Japanese)

YAO HSUEH HSUEH PAO [ACTA PHARMACEUTICA SINICA]
Pei YH Li X Zhu TR
[Studies on the structure of a new ellagic acid glycoside from the root-sprouts of Agrimonia pilosa Ledeb]
Yao Hsueh Hsueh Pao 1990;25(10):798-800 (Published in Chinese)
Four compounds were isolated from the root-sprouts of Agrimonia pilosa Ledeb. On the basis of physico-chemical properties, spectroscopy (UV, IR, NMR, MS) and chemical degradation, a new compound was elucidated as ellagic acid-4-O-beta-D-xylopyranoside (XV), and three known compounds were identified as agrimonolide (XIII), tormentic acid (XIV), and ellagic acid (XVI). Pei YH Li X Zhu TR Wu LJ
[Studies on the structure of a new flavanonol glucoside of the root- sprouts of Agrimonia pilosa Ledeb]
Yao Hsueh Hsueh Pao 1990;25(4):267-70 (Published in Chinese)
Three compounds were isolated from benzene and acetone extracts of the root-sprouts of Agrimonia pilosa Ledeb. On the basis of physicochemical properties, spectroscopy (UV, IR, NMR, MS, CD, GC) and chemical degradation, two known compounds were identified as palmitic acid (VIII) and daucosterol (IX), one new compound was elucidated as (2S,3S)-(-)-taxifolin-3-O-beta-D-glucopyranoside (X).

Pei YH Li X Zhu TR
[Studies on the structure of a new isocoumarin glucoside of the root sprouts of Agrimonia pilosa Ledeb]
Yao Hsueh Hsueh Pao 1989;24(11):837-40 (Published in Chinese) Trans-p-hydroxycinnamic esters VI and an isocoumarin glucoside VII were isolated from the benzene and acetone extracts of the root sprouts of Agrimonia pilosa Ledeb. On the basis of physicochemical properties, spectral data (UV, IR, NMR, MS, CI-MS-MS), GC and chemical degradation, VI was elucidated as trans-p-hybroxycinnamic esters of n-C22, n-C24-32, n-C34, alcohols, VII was elucidated as agrimonolide-6-Q-beta-D-glucopyranoside. VII and trans-p- hydroxycinnamic esters of n-C29-32 and n-C34 alcohols are new compounds.

Pei YH Li X Zhu TR
[Studies on the chemical constituents from the root-sprouts of Agrimonia pilosa Ledeb]
Yao Hsueh Hsueh Pao 1989;24(6):431-7 (Published in Chinese)
Five compounds were isolated from the petroleum ether extract of the root-sprouts of Agrimonia pilosa Ledob. A new compound, (R)-(-)- agrimol B (III), was elucidated by means of physical and chemical properties, spectroscopy (MS, IR, PMR, UV) and total synthesis. Four known compounds were identified as agrimophol (I), n-nonacosane (II), beta-sitosterol (IV) and pseudo-aspidin (V), the last one being previously known only as a synthetic entity. (S)-(+)-Agrimol B also was synthesized.

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